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Beschreibung

A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38alpha and p38beta2 (82% and 93% inhibition with 1 µ,M inhibitor, respectively, IC50 of p38alpha inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38gamma, p38delta, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.