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Beschreibung

A cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 380 nM for p38alpha). Shown to effectively suppress LPS-induced cytokine release in vitro (IC50 = 160 nM for TNF-alpha release and 39 nM for IL-1beta release, human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-alpha release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models.