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JAK2 Inhibitor IV - CAS 1110502-30-1 - Calbiochem The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Artikelnr.

SAF-420139-5MG

Einheit

1 x 5 mg

Transportdaten

No Dangerous Good

Preis auf Anfrage

Beschreibung

An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µ,M).

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