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Beschreibung

A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38alpha, and a panel of more than 30 other kinases (pIC50<5.0). In contrast, SP600125 offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions.

Strukturformel

JNK Inhibitor IX

Inhalte

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