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Beschreibung

A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/&beta,-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished &beta,-catenin/p300 interaction and a concomitant increase in &beta,-catenin/CBP usage. Co-adminitration of IQ-1 (4 microg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.