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Beschreibung

A 14-amino acid peptide corresponding to the active IkappaB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IkappaB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 mug/ml) and prevents NF-kappaB activation., A 14-amino acid peptide corresponding to the active IkappaB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IkappaB degradation by IkappaB kinases (IKK) in RAW 264.7 cells (<50 µ,g/ml) and prevents NF-kappaB activation. Supplied as a trifluoroacetate salt.