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Beschreibung

A cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1alpha protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µ,M, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1alpha induced by IGF-1 in HCT116 human colon carcinoma cells.