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Beschreibung

A cell-permeable xanthene compound that binds to Gbetagamma with high affinity (Kd ~400 nM derived from a surface plasma resonance binding study using Gbeta1gamma2) and blocks Gbetagamma-dependent cellular activities. Reported to exhibit in vivo prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model via either intraperitoneal or oral administration.