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Beschreibung

A cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µ,M for rat liver and human recombinant CKII, respectively) and DYRK (IC50<1 µ,M for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µ,M using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µ,M and 900 nM using DNA and RNA substrates, respectively).