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Beschreibung

A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe, 0.3 µ,M for CK1delta) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38alpha MAP kinase (IC50 = 12 µ,M) and several other kinases tested, including PKB, SGK, and GSK-3beta. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090, IC50 = 2.5 µ,M for CK1).