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Beschreibung

Full-length, recombinant human calmodulin fused to a His.Tag sequence at the N-terminus. Contains four functional Ca2+-binding sites (aa 20-31, aa 56-67, aa 93-104, aa 129-140) with EF-hands (aa 7-42, aa 43-78, aa 80-115, aa 116-148), and a ubiquitination site at Lys21. This preparation is qualified for use as a substrate for protein tyrosine kinases in in vitro assays. Through its interaction with Ca2+, calmodulin mediates the control of a large number of enzymes, including protein kinases and phosphatases. It is expected to be phosphorylated at Thr44 by CaMK4. In addition, it serves as a substrate for various protein tyrosine kinases.