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Beschreibung

N-terminal 6His-tagged recombinant human Tie2 residues 771-end., Expressed by baculovirus in Sf21 insect cell., Tyrosine 1108 has been identified as an autophosphorylation site in human Tie2. The Y1106F substitution in murine Tie2 (analogous to Y1108F in human Tie2) has been shown to block cell migration by disrupting binding of Tie2 to the docking protein Dok-R (Jones N., et al., Mol Cell Biol.(2003),23:2658-2668 and Murray B.W., et al., Biochemistry.(2001),40:10243-10253).