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Beschreibung

Peptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (Ki = 2.3 nM)., A potent synthetic peptide that is a competitive inhibitor of protein kinase A (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate.