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Beschreibung

Category: Carbohydrates and Derivatives, Chiral Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Dark Red Solid /// Application Notes: Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the beta-ligand of the cobalt are termed cobalamins. Synthesized almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products, plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment. /// References: Rickes, et al.: Science, 107, 396 (1948)| Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981)| Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)