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Category: Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: dl-alpha-Tocopherol Succinate is the racemic analog of alpha-Tocopheryl Succinate (T539950), a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines. /// References: Weber, T. et al.: Clin. Can Res., 8, 863 (2002)|Staphelberg, M. et al.: Biochem. Biophys. Res. Comm., 318, 636 (2004)| Ramathapuram, L.V. et al.: Cancer Immunol. Immununother., 55, 166 (2005)|