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Beschreibung

Category: Amines, Aromatics, Catalyst, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: White Solid /// Application Notes: (1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine is used as a catalyst in the synthesis of keramamine C, a carboline alkaloid that is isolated from the Okinawan sponge Amphimedon sp. (1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine is also used as a catalyst in the synthesis of Tolvaptan (T536650), a selective oral vasopressin V2-receptor agonist that is used to treat hyponatremia. /// References: Hu, J., et al.: Alkaloid. New York-Acad. Press, 60, 207 (2003)| Ishiyama, H., et al.: Heterocycles, 86, 1009 (2012)| Schrier, R., et al.: New Engl. J. Med., 355, 2099 (2006)| Yin, L., et al.: Tetrahedron-Assymetr., 21, 2390 (2010)