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Beschreibung

Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Tyrosine Kinase Inhibitors /// Appearance: Off-White to Pale Beige Solid /// Application Notes: A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000). /// References: David, E., et al.: Blood, 116, 5285 (2010)| Nagai, T., et al.: Leukemia Res., 34, 1057 (2010)| Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)