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Category: Amines, Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: Suvorexant-d6 is the labeled analog of Suvorexant (S870000), a dual (non-selective) orexin receptor antagonist in development by Merck and Co. for the treatment of insomnia. It works by turning off wakefulness rather than by inducing sleep. Users of higher doses had an increased rate of suicidal ideation. /// References: Cox, C., et al.: J. Med. Chem., 53, 5320 (2010)| Baxter, C., et al.: Org. Process Res. Dev., 15, 367 (2011)| Winrow, C., et al.: J. Neurogenet., 25, 52 (2011)| Mieda, M., et al.: CNS Drugs, 27, 83 (2013)| Osborne, R.: Nat. Rev. Drug Discov., 12, 492 (2013)