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Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Pale Beige Solid /// Application Notes: Suvorexant (MK-4305) is a dual (non-selective) orexin receptor antagonist in development by Merck and Co. for the treatment of insomnia. It works by turning off wakefulness rather than by inducing sleep. Users of higher doses had an increased rate of suicidal ideation. /// References: Cox, C., et al.: J. Med. Chem., 53, 5320 (2010)| Baxter, C., et al.: Org. Process Res. Dev., 15, 367 (2011)| Winrow, C., et al.: J. Neurogenet., 25, 52 (2011)| Mieda, M., et al.: CNS Drugs, 27, 83 (2013)| Osborne, R.: Nat. Rev. Drug Discov., 12, 492 (2013)