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Beschreibung

Category: Cross Linking Reagents, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: A short, amino reactive homobifunctional crosslinking reagent. Crosslinking distance 8.3 ?. It is useful in polymer coupling to proteins, because it may lead to a better selectivity among all the amino groups present in a protein, thus yielding less heterogeneous PEG-protein conjugates mixture because only the most nucleophilic and solvent exposed amines can react. /// References: Gross, H., et al.: Tetrahedron, 24, 6935 (1968), Clark, R., et al.: J. Biol. Chem., 271, 21969 (1996), Guiotto, A., et al.: Bioorg. Med. Chem., 12, 5031 (2004), XXX