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Application Notes: D-Serine-2,3,3-d3 is derived from 2-Chlorobenzyl Chloride (C364225), which is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity. /// References: Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015)| Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)