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Category: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: Semagacestat is an inhibitor of the gamma-secretase enzyme. gamma-Secretase enzyme is pivotal in the generation of beta-amyloid (Abeta), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD). /// References: Portelius, E. et al.: Alzheim. Res. Ther., 22. No pp. given (2010)| Imbimbo, B.P. et al.: Curr. Opin. Invest. Drugs, 10, 721 (2009)| Panza, F. et al.: Curr. Med. Chem., 18, 5430 (2011)|