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Category: Aromatics, Heterocycles, NeuroChemicals Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: RTI-113 is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence. /// References: Dworkin, S. et al.: Synapse, 30, 49 (1998)| Negus, S.S. et al.: Pharmacol. Biochem. Behav., 91, 333 (2009)| Cook, C. et al.: Eur. J. Pharmacol., 442, 93 (2002)|