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Beschreibung

Category: Aromatics, Heterocycles, Metabolites and Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Light Yellowish Orange to Brownish Yellow Solid /// Application Notes: Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase. /// References: Vickers, P.J. et al.: Can. J. Biochem. Cell Biol., 63, 777 (1985): Tafolla, W.H. et al.: J. Pharmac. Sci., 70, 1273 (1981)| Iwai, K. et al.: J. Butrit. Sci. Vitaminol., 23, 95 (1977)|