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Category: Amines, Aromatics, Drug Analogues, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Dark Blue Solid /// Application Notes: Pixantrone is an antineoplastic drug belonging to group of antitumor antibiotics. Pixantrone is an anlogue of Mitoxantrone (M373425) and is just as potent in the treatment of multiple sclerosis with fewer toxic effects on cardiac tissue. Studies suggest that Pixantrone significantly reduces amyloid beta (A beta(1-42)) neurotoxicity, a mechanism implicated in Alzheimer's disease. /// References: Cavalletti, E. et al.: Invest. New Drugs, 25, 187 (2007)| Gonsette, R.E. et al.: J. Neurol. Sci., 223, 81 (2004)| Colombo, R. et al.: Electrophoresis, 30, 1418 (2009)