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Beschreibung

Category: Amines, Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White Solid /// Application Notes: Labelled analogue of Pimozide, a D2 dopamine receptor antagonist. Pimozide binds with high affinity to the cloned 5-HT7 receptor. Pimozide is also a Ca2+ channel antagonist. Pimozide is used as an antipsychotic. /// References: Liu, J., et al.: Br. J. Pharmacol., 126, 245 (1999)| Richelson, E., et al.: Life Sci., 68, 29 (2000)| Santi, C., et al.: J. Neurosci., 22, 396 (2002)| Mariot, P., et al.: J. Biol. Chem., 277, 10824 (2002)| Nikonenko, I., et al.: Mol. Pharmacol., 68, 84 (2005)|