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Category: Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction. /// References: Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992)| Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996)| Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998)|