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Category: Aromatics, Amines, Pharmaceuticals, Intermediates and Fine Chemicals, Protein Kinase Inhibitors and Activators, Pfizer compounds /// Appearance: Off-White Solid /// Application Notes: PD-184161 is a novel mitogen-activated protein kinase kinase (MEK) inhibitor shown to exhibit antitumor effects and suppress MEK-extracellular signal-related kinase signaling activity and cell proliferation in human hepatocellular carcinoma cells and in human hepatocellular carcinoma xenografts. /// References: Yip-Schneider, M.T. et al.: J. Pharmacol. Exp. Therap., 329, 1063 (2009)| Klein, P.J. et al.: Neoplasia, 8, 1 (2006)| Yung, H.W. et al.: Biochem. Pharmacol., 68, 351 (2004)|