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Beschreibung

Category: Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals, Pfizer compounds /// Appearance: Pale Beige Solid /// Application Notes: A selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-alpha-induced damage to human renal proximal tubular epithelial cells /// References: Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010)| Kagawa, T. et al.: Nephrol., 13, 309 (2008)| Cohen, E.P. et al.: Transl. Res., 150, 106 (2007)|