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Category: Amines, Aromatics, Isotope Labelled Compounds, Nicotine Derivatives, Nucleotides, Bases and Related Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: beta-Nicotinamide-d4 Mononucleotide is the labelled analogue of a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. /// References: Yoshino, J. et al.: Cell Metab., 14, 528 (2011)| Caton, P.W. et al.: Diabetologia, 54, 3083 (2011)| Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009)|