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Beschreibung

Category: Aromatics, Heterocycles, Indole Derivatives, Inhibitors, Fluorescent Labels and Indicators, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Yellow Solid /// Application Notes: trans-Ned-19 is a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be used as a chemical proble since it fluorescentey labels NAADP receptors in intact cells. /// References: Rosen, D. et al.: J. Biol. Chem., 284, 34930 (2009)| Naylor, E. et al.: Nat. Chem. Biol., 5, 220 (2009)| Thai, T.L. et al.: Am. J. Physiol. Renal Physiol., 297, F510 (2009)|