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Category: Agonists, Chiral Reagents, Heterocycles, Isotope Labelled Compounds, Neurochemicals, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: 6S-Nalfurafine-d3 is the labeled analogue of 6S-Nalfurafine (N255615), a stereoisomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid ?-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients. /// References: Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004)| Mori, T., et al.: Life Sci., 75, 2433 (2004)| Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006)| Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)