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Category: Aromatics, Amines, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: 6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia. /// References: Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23 (16), 4493 (2013)|