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Beschreibung

Appearance: Clear Colourless Oil /// Application Notes: Metanicotine-d3 is the isotope labelled analog of Metanicotine (M321250), an alkaloid found in the leaves of Duboisia Hopwoodii and a constitutent of tobacco smoke. Also used as a potential drug for the treatment of senile dementia of the Alzheimer's type, and currently being investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to peripheral ganglionic and muscle-type nicotinic acetylcholine receptors. /// References: Schmeltz, I., et al.: J. Sci. Food Agric., 15, 744 (1964)| Griffin, W.J. and Luanratana, O.: Phytochemistry, 21, 499 (1982)| Jacob III, P., et al.: J. Chromatogr., 619, 49 (1993)| Lippiello, P.M., et al.: J. Pharm. Exp. Therap., 279, 1422 (1996)