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Beschreibung

Category: Nicotine Derivatives, /// Appearance: Clear Colorless to Pale Yellow Oil /// Application Notes: An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer's type and currently being investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to peripheral ganglionic and muscle-type nicotinic acetylcholine receptors. /// References: Schmeltz, I., et al.: J. Sci. Food Agric., 15, 744 (1964), Griffin, W.J. and Luanratana, O.: Phytochemistry, 21, 499 (1982), Jacob III, P., et al.: J. Chromatogr., 619, 49 (1993), Lippiello, P.M., et al.: J. Pharm. Exp. Therap., 279, 1422 (1996)