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Appearance: Off-White Solid /// Application Notes: N-Methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-glycine Methyl Ester is an intermediate in the synthesis of Cyclosporin AM 4N (C989410), a metabolite of Cyclosporin A (C988900). Cyclosporin A is a hydrophobic cyclic undecapeptide that is used as a potent immunosuppressive agent that has application in human organ transplantation. Cyclosporin A works by inhibiting subsets of T lymphocytes to facilitate organ transplantation. /// References: Brooks, C., et al.: Clin. Chem., 39, 457 (1993)| Colombani, P., et al.: Science, 228, 337 (1985)|Kr?nke, M., et al.: Proc. Nat. Acad. Sci., 81, 5214 (1984)| Liu, J., et al.: Cell, 66, 807 (1991)| Serino, F., et al.: Mol. Cell. Biochem., 122, 101 (1993)