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Category: Miscellaneous Reagents /// Appearance: Pale Blue Oil /// Application Notes: Methyl chloroacetate is widely used in the chemical and biochemical fields as an extraction solvent. Methyl chloroacetate is known to induce DNA damage to rat sperm, and is also thought to be toxic to humans upon exposure. Methyl chloroacetate is also used as a reagent to synthesize Valdecoxib (V090000), a selective cyclooxygenase 2(COX-2) specific inhibitor that is used to treat postoperative pain. /// References: Nussmeier, N., et al.: New Engl. J. Med., 352, 1081 (2005)| Talley, J., et al.: J. Med. Chem., 43, 775 (2000)| Wang, T., et al.: J. Chromatogr. A, 1147, 105 (2007)| Wenye, L.: J. Anh. Agri. Sci., 35, 2581 (2007)