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Beschreibung

Category: Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: Light Yellow Solid /// Application Notes: A potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between beta-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. /// References: Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011)| Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011)|