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Category: Aromatics, Metabolites and Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: alpha-Hydroxy-alpha-3-thienyl-2-thiopheneacetic Acid 9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester is an impurity in the synthesis of Tiotropium Bromide (T444850), a muscarinic receptor antagonist. Bronchodilator. /// References: Rodgers, T. et al.: J. Med. Chem., 20, 591 (1977)| Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994)| Donohue, J. F., et al.: Chest, 122, 47 (2002)| Profita, M., et al.: Allergy, 60, 1361 (2005)| Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006)|