Zurück zu Ihrem Suchergebnis

Beschreibung

Category: Metabolites, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Pale Yellow Solid /// Application Notes: Isotope labelled Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.This compound is suitable for aldehyde dehydrogenase (ALDH) related research. /// References: Struck, R.F., et al.: Cancer. Rsch., 34, 2933 (1947)| Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)