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Beschreibung

Category: Amines, Miscellaneous Reagents /// Appearance: Clear Colourless to Pale Yellow Oil /// Application Notes: Ethyl 3-Aminocrotonate is used as a reagent to synthesize Nitrendipine (N490150), a calcium channel antagonist that is used to treat patients with hypertension. Ethyl 3-Aminocrotonate is also used as a reagent to synthesize (S)-Felodipine (F232370), a calcium entry blocker that has antihypertensive properties. /// References: Bailey, D., et al.: Clin. Invest. Med., 12, 357 (1989)| Bean, B.: Proc. Nat. Acad. Sci., 81, 6388 (1984)| Kwon, K., et al.: Tetrahedron, 67, 10222 (2011)| Leenen, F. & Holiwell, D.: Am. J. Cardio., 69, 639 (1992)| Meyer, H., et al.: Arz. Forsch., 33, 1528 (1983)| Stoepel, K., et al.: Arz. Forsch., 31, 2056 (1980)