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Category: Pharmaceuticals, Intermediates and Fine Chemicals, Steroids, /// Appearance: White to Off-White Solid /// Application Notes: Estradiol (known as alpha-Estradiol or 17 alpha-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-?stradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain(1,2). 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer's disease and ischemic stroke(3).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants, Food contaminants.