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Category: Amines, Aromatics, Chiral Reagents, Drug Analogues, Heterocycles, Nucleotides, Bases and Related Reagents, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: Off-White Solid /// Application Notes: 5-epi Emtricitabine is an epimer of Emtricitabine (E525000), a nucleoside reverse transcriptase inhibitor approved for treatment of human immunodeficiency virus (HIV) 1, and also has antagonistic activity against the hepatitis B virus. 5-epi Emtricitabine is also used as a reagent for the synthesis of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential HIV agents. /// References: Jeong, L., et al.: J. Med. Chem., 36, 181 (1993)| Lim, S. et al.: Arch. Intern. Med., 166, 49 (2006)| Smith, K., et al.: AIDS, 23, 1547 (2009)