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Category: Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Foam /// Application Notes: (alphaR,deltaS,gammaR)-delta-[[(1,1-Dimethylethoxy)carbonyl]amino]-gamma-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-alpha-(phenylmethyl)benzenehexanoic Acid is an intermediate in the synthesis of gamma-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid beta-peptide (Abeta), the major causative agent in Alzheimer disease (AD). /// References: Crump, C.J., et al.: Biorg. Med. Chem. Lett., 22, 2997 (2012)|