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Category: Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: N-[(2R,4R,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide, is a gamma-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid beta-peptide (Abeta), the major causative agent in Alzheimer disease (AD). /// References: Schedin-Weiss, S., et al.: PLoS One, 8, 63962 (2013)| Wanngren, J., et al.: J. Bio. Chem., 287, 32640 (2012)|