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Appearance: White to Off-White Solid /// Application Notes: 1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluorophenyl)-1-butanone is an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985), which is an impurity of Sitagliptin (S491000), a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes. /// References: Kim, D., et al.: J. Med. Chem. 48, 141 (2005)| Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005)|