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Category: Agonist, Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Orange Brown Solid /// Application Notes: 4'-Dimethylamino 7,8-Dihydroxyflavone is a synthetic 7,8-Dihydroxyflavone derivative which promotes neurogenesis and exhibits potent antidepressant effect. The 7,8-dihydroxy groups are essential for the agonistic effect. 4'-Dimethylamino 7,8-Dihydroxyflavone displays higher TrkB agonistic activity than that of 7,8-Dihydroxyflavone (D452830). /// References: Thoenen, H., et al.: Trends Neurosci., 14, 165 (1991)| Nibuya, M., et al.: J. Neurosci., 15, 7539 (1995)| Kaplan, D., et al.: Curr. Opin. Neurobiol., 10, 381 (2000)| Saarelainen, T., et al.: J. Neurosci., 2003, 23, 349 (2003)|