Zurück zu Ihrem Suchergebnis

Beschreibung

Category: Amines, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Clear Colourless to Pale Yellow Thick Oil /// Application Notes: (S)-N-((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylacetamide is a derivative of (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane (D461760, HCl), an intermediate in the synthesis of Ivabradine (I940500, HCl) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Also an antianginal. /// References: Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994)| Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998)| Borer, J.S., et al.: Circulation, 107, 817 (2003)| DiFrancesco, D., et al.: Drugs, 64, 1757 (2004)