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Category: Aromatics, Heterocycles, Mutagenesis Research Chemicals /// Appearance: Dark Grey Solid /// Application Notes: trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene (B205800). Benzo[a]pyrene (B205800), a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene (D452280) undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2'-deoxyguanosine. A carcinogen. /// References: Gelhaus, S. et al: Chem. Res. Toxicol., 24, 89 (2011)| Belvedere, G. et al.: Biochem. Pharmacol., 29, 1693 (1980)| Jennette, K. et al.: Biochem. Pharmacol., 28, 338 (1979)| Yagi, H. et al.: J. Am. Chem. Soc., 99, 2358 (1977)