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Beschreibung

Category: Amines, Chiral Reagents, Heterocycles, Isotope Labelled Compounds, Nucleotides, Bases and Related Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: The labelled reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 µM. /// References: Shen, R., et al.: Biochim Biophys Acta., 965, 9 (1988), Kwon, N.S., et al.: J. Biol. Chem., 264, 20498 (1989), Werner, E.R., et al.: Proc. Soc. Exp. Biol. Med., 203, 1 (1993)